Zmudzinska Maria, Czarnecka-Operacz Magdalena, Silny Wojciech
Department of Dermatology, Allergic Diseases Deagnostic Centre, Poznan University of Medical Sciences, Poznan, Poland.
Acta Dermatovenerol Croat. 2008;16(2):72-8.
The aim of the study was to assess the prevalence of contact allergy to glucocorticosteroids in patients with chronic venous leg ulcers (CVLU), atopic dermatitis (AD) and contact dermatitis (CD), and in a group of healthy individuals; and to estimate differences among these patient groups. Patch tests with the European standard series, antibiotics, glucocorticosteroid contact allergy screening markers and ointment vehicles were performed in a population of 140 patients. Positive patch tests results were recorded in 80% and contact allergy to glucocorticosteroids in 40% of CVLU patients. In the group of AD patients, the respective figures were 30% and 3%. In the group of CD patients, allergic type of disease was detected in 80% and positive patch tests for glucocorticosteroids in 20% of patients. In healthy individuals, allergic contact reaction was observed in 17% of cases. Statistically significant differences among patient groups were found according to the prevalence of contact allergy, polyvalent allergy and contact allergy to glucocorticosteroids. We suggest that glucocorticosteroid contact allergy should be considered as a crucial clinical problem in patients with inflammatory dermatoses like CVLU, AD and CD.
该研究的目的是评估慢性腿部静脉溃疡（CVLU）、特应性皮炎（AD）和接触性皮炎（CD）患者以及一组健康个体中对糖皮质激素接触过敏的患病率；并估计这些患者群体之间的差异。对140名患者进行了欧洲标准系列、抗生素、糖皮质激素接触过敏筛查标记物和软膏基质的斑贴试验。CVLU患者中80%斑贴试验结果呈阳性，40%对糖皮质激素接触过敏。在AD患者组中，相应数字分别为30%和3%。在CD患者组中，80%检测出过敏性疾病类型，20%患者糖皮质激素斑贴试验呈阳性。在健康个体中，17%的病例观察到过敏性接触反应。根据接触过敏、多价过敏和对糖皮质激素接触过敏的患病率，发现患者群体之间存在统计学显著差异。我们建议，对于CVLU、AD和CD等炎症性皮肤病患者，应将糖皮质激素接触过敏视为一个关键的临床问题。
