Thurber Greg M, Schmidt Michael M, Wittrup K Dane
Department Chemical Engineering, Massachusetts Institute of Technology, USA.
Adv Drug Deliv Rev. 2008 Sep;60(12):1421-34. doi: 10.1016/j.addr.2008.04.012. Epub 2008 Apr 24.
Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous distribution of these agents in tumors when administered systemically. Large regions of untargeted cells can therefore escape therapy and potentially select for more resistant cells. We present here a summary of theoretical and experimental approaches to analyze and improve antibody penetration in tumor tissue.
抗体已被证明是癌症成像和治疗中的有效药物。该领域仍然面临的主要挑战之一是,当全身给药时,这些药物在肿瘤中的分布不均。因此,大量未靶向的细胞区域可能会逃避治疗,并可能选择出更具抗性的细胞。我们在此总结了分析和改善抗体在肿瘤组织中渗透的理论和实验方法。