Weinstein Laura A, Wei Bingqing
Department of Biomedical Engineering, University of Delaware, Newark 19716, DE, USA.
Department of Mechanical Engineering, University of Delaware, Newark 19716, DE, USA.
Nanomaterials (Basel). 2025 May 15;15(10):739. doi: 10.3390/nano15100739.
The field of nanomedicine has been fruitful in creating novel drug delivery ideas to battle hematologic cancers. However, one persistent barrier to efficient nanoparticle treatment is phagocytic uptake or the clearance of nanoparticles by immune cells. To prevent this immune uptake, scientists have utilized biomimicry, the emulation of natural structures for engineered applications, to create particles that are able to remain unrecognized by immune cells. This method aims to improve the overall circulation time of nanoparticles by decreasing the amount of particles filtered out of the blood. It can even lead to homotypic cancer cell targeting, decreasing cancer cell vitality. This review summarizes recent in vivo and in vitro studies to prove that biomimetic cargo delivery is a unique and tenable way of increasing survival outcomes in patients with hematologic cancers.
纳米医学领域在创造新型药物递送理念以对抗血液系统癌症方面成果丰硕。然而，高效纳米颗粒治疗的一个持续障碍是吞噬摄取，即免疫细胞对纳米颗粒的清除。为防止这种免疫摄取，科学家利用了仿生学，即将自然结构模仿用于工程应用，来制造能够不被免疫细胞识别的颗粒。该方法旨在通过减少从血液中滤出的颗粒数量来提高纳米颗粒的整体循环时间。它甚至可以导致同型癌细胞靶向，降低癌细胞活力。本综述总结了近期的体内和体外研究，以证明仿生载药递送是提高血液系统癌症患者生存结局的一种独特且可行的方法。
