结核分枝杆菌临床分离株中与链霉素耐药相关的突变鉴定及外排机制的可能作用
Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism.
作者信息
Spies Fernanda S, da Silva Pedro E Almeida, Ribeiro Marta O, Rossetti Maria Lucia, Zaha Arnaldo
机构信息
Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
出版信息
Antimicrob Agents Chemother. 2008 Aug;52(8):2947-9. doi: 10.1128/AAC.01570-07. Epub 2008 Jun 9.
Abstract
The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.
摘要
在存在外排泵（EP）抑制剂的情况下链霉素的最低抑菌浓度（MIC）以及rpsL、rrs和gidB基因的测序结果为EP可能参与某些无突变分离株的低水平链霉素（STR）耐药性提供了证据。gidB基因的突变和EP可能协同作用导致低水平的STR耐药性。
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