Modulation of the intestinal flora of mice by treatment with aztreonam and tigemonam.
作者信息
van Ogtrop M L, Guiot H F, Mattie H, van Strijen E, Sekh B R, van Furth R
机构信息
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
出版信息
Antimicrob Agents Chemother. 1991 May;35(5):983-5. doi: 10.1128/AAC.35.5.983.
Abstract
Oral and parenteral administration of aztreonam and oral administration of tigemonam to conventional mice caused a decrease in the number of aerobic gram-negative rods in the feces. Oral treatment with high doses of aztreonam (greater than or equal to 25 mg/kg/day) and tigemonam (100 mg/kg/day) adversely influenced colonization resistance, whereas oral treatment with lower doses of the monobactams or parenteral treatment with aztreonam did not.
摘要
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