Jones P G, Bodey G P, Swabb E A, Rosenbaum B
Antimicrob Agents Chemother. 1984 Dec;26(6):941-3. doi: 10.1128/AAC.26.6.941.
Eighteen patients with hematological malignancies received aztreonam in one of two dosing regimens, 1 or 2 g every 8 h for a total of 7 to 9 days. Throat and stool cultures were obtained before and during treatment with aztreonam. Aztreonam had little effect on the predominant throat flora. In contrast, facultatively anaerobic gram-negative bacilli were markedly decreased in stools during the administration of aztreonam. Strict anaerobes in the stool were variably affected by aztreonam.
18例血液系统恶性肿瘤患者接受了氨曲南治疗,采用两种给药方案之一,即每8小时1或2克,共7至9天。在氨曲南治疗前和治疗期间进行了咽喉和粪便培养。氨曲南对咽喉部主要菌群影响较小。相比之下,在使用氨曲南期间,粪便中兼性厌氧革兰氏阴性杆菌明显减少。粪便中的严格厌氧菌受氨曲南的影响各不相同。