Gelber R H, Siu P, Tsang M, Alley P, Murray L P
Kuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco, California 94115-1896.
Antimicrob Agents Chemother. 1991 May;35(5):992-4. doi: 10.1128/AAC.35.5.992.
We evaluated the minimal concentrations of minocycline in the diet and in serum required to inhibit the growth of seven Mycobacterium leprae isolates in mice. Minocycline concentrations of 0.01 and 0.04% in the diet, which resulted in levels in serum of less than or equal to 0.17 and 0.51 microgram/ml, respectively, were consistently and completely inhibitory. Even 0.004% dietary minocycline (levels in serum, less than or equal to 0.08 microgram/ml) partially inhibited five of these strains, while 0.001% minocycline was consistently inactive. For five of these isolates, minocycline at a concentration of 0.04% in the diet given 3 days (Monday, Wednesday, Friday) and 1 day weekly completely inhibited the growth of M. leprae, and minocycline given even 1 day monthly was partially inhibitory for three of these five M. leprae isolates.
我们评估了饮食和血清中米诺环素抑制小鼠体内七种麻风分枝杆菌分离株生长所需的最低浓度。饮食中米诺环素浓度为0.01%和0.04%时，血清水平分别低于或等于0.17微克/毫升和0.51微克/毫升，始终具有完全抑制作用。即使饮食中米诺环素浓度为0.004%（血清水平低于或等于0.08微克/毫升）也能部分抑制其中五种菌株，而0.001%的米诺环素始终无活性。对于其中五种分离株，饮食中浓度为0.04%的米诺环素在每周给药3天（周一、周三、周五）和每周给药1天的情况下，完全抑制了麻风分枝杆菌的生长，甚至每月给药1天的米诺环素对这五种麻风分枝杆菌分离株中的三种也有部分抑制作用。
