多种喹诺酮类抗生素对感染小鼠体内麻风分枝杆菌的活性。
Activities of various quinolone antibiotics against Mycobacterium leprae in infected mice.
作者信息
Gelber R H, Iranmanesh A, Murray L, Siu P, Tsang M
机构信息
Medical Research Institute, California Pacific Medical Center, San Francisco 94115.
出版信息
Antimicrob Agents Chemother. 1992 Nov;36(11):2544-7. doi: 10.1128/AAC.36.11.2544.
Abstract
Previously, pefloxacin and ofloxacin were found to be active against Mycobacterium leprae in vitro, in experimental animals, and in clinical trials of lepromatous leprosy patients. In this study, we compared certain more recently developed fluoroquinolones (lomefloxacin, PD 124816, WIN 57273, temafloxacin, and sparfloxacin) with pefloxacin and ofloxacin in M. leprae-infected mice at doses of 50, 150, and 300 mg/kg given five times weekly. All seven of the fluoroquinolones studies were active against M. leprae; temafloxacin and sparfloxacin were the most active, being fully bactericidal at all three dosage schedules. Additionally, sparfloxacin was found to be fully bactericidal at 15 and 30 mg/kg given five times weekly.
摘要
先前发现，培氟沙星和氧氟沙星在体外、实验动物以及瘤型麻风病人的临床试验中对麻风杆菌有活性。在本研究中，我们将某些最近开发的氟喹诺酮类药物（洛美沙星、PD 124816、WIN 57273、替马沙星和司帕沙星）与培氟沙星和氧氟沙星在感染麻风杆菌的小鼠中进行比较，每周给药5次，剂量分别为50、150和300mg/kg。所研究的所有7种氟喹诺酮类药物对麻风杆菌均有活性；替马沙星和司帕沙星活性最强，在所有3种给药方案下均具有完全杀菌作用。此外，发现司帕沙星在每周给药5次、剂量为15和30mg/kg时具有完全杀菌作用。
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