Coupaye Muriel, Puchaux Karin, Bogard Catherine, Msika Simon, Jouet Pauline, Clerici Christine, Larger Etienne, Ledoux Séverine
Explorations Fonctionnelles, Centre de référence de l'Obésité, Hôpital Louis Mourier (AP-HP), 178 rue des Renouillers, 92700, Colombes, France.
Obes Surg. 2009 Jan;19(1):56-65. doi: 10.1007/s11695-008-9571-2. Epub 2008 Jun 10.
Gastric bypass (GBP) is more efficient than adjustable gastric banding (AGB) on weight loss and comorbidities, but potentially induces more nutritional deficits. However, no study has compared the prevalence of nutritional deficiencies after these two bariatric procedures. WE PROSPECTIVELY COMPARED: To prospectively compare the prevalence of nutritional deficiencies after AGB and GBP.
We have performed a 1-year prospective study of nutritional parameters in 70 consecutive severe obese patients, who had undergone bariatric surgery, 21 AGB and 49 GBP. After GBP, multivitamin supplements were systematically prescribed and vitamin B12 supplementation was introduced if a deficiency was observed.
Patients lost more weight after GBP than after AGB (40 +/- 13 vs 16 +/- 8 kg, p < 0.001). Vitamins B1 and C and iron deficiencies were frequent before surgery but were not worsened by GBP. AGB only induced a slight decrease of vitamin B1 at 1 year, whereas GBP induced significant decreases of vitamins B12 and E, serum prealbumin, and creatinine concentrations, with only minor clinical consequences. Anemia was observed in 10% of the patients after bariatric surgery. Hemoglobin concentration was not correlated to vitamin B12 or folate concentrations but was related to iron status. Risk of iron deficiency anemia was better assessed by transferrin saturation than by serum ferritin concentration in this obese population.
Severe nutritional deficits can be avoided after bariatric surgery if patients are systematically supplemented with multivitamin and carefully monitored. However, specific care is required to avoid iron and vitamin B12 deficiencies, anemia, and protein malnutrition.
胃旁路手术(GBP)在减重和治疗合并症方面比可调节胃束带术(AGB)更有效,但可能导致更多营养缺乏。然而,尚无研究比较这两种减肥手术后营养缺乏的发生率。我们进行前瞻性比较:前瞻性比较AGB和GBP术后营养缺乏的发生率。
我们对70例连续接受减肥手术的严重肥胖患者进行了为期1年的营养参数前瞻性研究,其中21例行AGB,49例行GBP。GBP术后,系统地开具多种维生素补充剂,如发现缺乏则补充维生素B12。
GBP术后患者体重减轻比AGB术后更多(40±13 vs 16±8 kg,p<0.001)。维生素B1、C和铁缺乏在手术前很常见,但GBP并未使其恶化。AGB仅在1年后导致维生素B1略有下降,而GBP导致维生素B12、E、血清前白蛋白和肌酐浓度显著下降,仅产生轻微临床后果。减肥手术后10%的患者出现贫血。血红蛋白浓度与维生素B12或叶酸浓度无关,但与铁状态有关。在该肥胖人群中,通过转铁蛋白饱和度评估缺铁性贫血风险比通过血清铁蛋白浓度更好。
如果患者系统补充多种维生素并仔细监测,减肥手术后可避免严重营养缺乏。然而,需要采取特殊护理措施以避免铁和维生素B12缺乏、贫血和蛋白质营养不良。