Saraceni V, King B S, Cavalcante S C, Golub J E, Lauria L M, Moulton L H, Chaisson R E, Durovni B
Rio de Janeiro City Health Secretariat, Rio de Janeiro, Rio de Janeiro, Brazil.
Int J Tuberc Lung Dis. 2008 Jul;12(7):769-72.
Data from the mortality database, Rio de Janeiro City (RJC) Health Department, Rio de Janeiro, Brazil.
To determine the role played by tuberculosis (TB) in Brazil's human immunodeficiency virus (HIV) positive population, we investigated the frequency of TB as the primary cause of death among HIV-positive subjects in RJC.
Information about acquired immune-deficiency syndrome (AIDS) deaths from 1996 to 2005 in individuals aged >12 years was obtained from the Mortality Information System (SIM), and the cause of death was classified according to the International Classification of Diseases (ICD-10), through primary causes coded in Chapter I--B20 to B24 (HIV disease).
There were 8601 AIDS-related deaths in RJC between 1996 and 2005. TB was the primary cause of death in 9.0% of all AIDS-related deaths, while Pneumocystis carinii pneumonia (PCP) accounted for 4.7%. TB cases erroneously classified under other infectious diseases may have contributed to an underestimation of the number of TB deaths among HIV-positive patients.
Our study showed that TB is the leading cause of AIDS-related deaths and is responsible for twice as many deaths as PCP, in a scenario of free access to antiretrovirals. The potential benefits of TB preventive treatment and of the availability of highly active antiretroviral treatment could not be established by this analysis.
数据来自巴西里约热内卢市（RJC）卫生部的死亡率数据库。
为确定结核病（TB）在巴西人类免疫缺陷病毒（HIV）阳性人群中所起的作用，我们调查了RJC中HIV阳性受试者中结核病作为主要死亡原因的发生频率。
从死亡信息系统（SIM）获取了1996年至2005年12岁以上个体的获得性免疫缺陷综合征（AIDS）死亡信息，根据国际疾病分类（ICD - 10），通过第一章中编码为B20至B24（HIV病）的主要病因对死亡原因进行分类。
1996年至200年期间，RJC有8601例与艾滋病相关的死亡。结核病是所有艾滋病相关死亡中9.0%的主要死亡原因，而卡氏肺孢子虫肺炎（PCP）占4.7%。错误分类在其他传染病下的结核病病例可能导致低估了HIV阳性患者中结核病死亡人数。
我们的研究表明，在可免费获得抗逆转录病毒药物的情况下，结核病是艾滋病相关死亡的主要原因，其导致的死亡人数是PCP的两倍。本分析无法确定结核病预防性治疗以及高效抗逆转录病毒治疗的潜在益处。
