Andreani A, Rambaldi M, Locatelli A, Conti M, Malandrino S
Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.
Acta Pharm Nord. 1991;3(1):5-8.
1-Phenylalkylindole-3-carboxylic acids 1-4, indole-1-acetic acids/esters 5-10 and the hydrazones 11-15 were prepared and submitted to the rat paw edema test using carrageenin. In the first two groups of compounds, the 2-chloro indoles were more active than the corresponding indole derivatives. In the third group the activity seemed to be determined largely by the substituent at the 1-position.
制备了1-苯基烷基吲哚-3-羧酸1-4、吲哚-1-乙酸/酯5-10和腙11-15，并使用角叉菜胶对其进行大鼠足跖水肿试验。在前两组化合物中，2-氯吲哚比相应的吲哚衍生物活性更高。在第三组中，活性似乎很大程度上由1-位的取代基决定。
