杂环化合物的研究。十七。2-甲基咪唑并[1,2-a]嘧啶-3-羧酸。
Research on heterocyclic compounds. XVII. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic acids.
作者信息
Abignente E, Arena F, Luraschi E, Saturnino C, Marmo E, De Rosis A, Filippelli A
出版信息
Farmaco Sci. 1984 May;39(5):379-88.
PMID:6610566
Abstract
A group of ethyl 2-methylimidazo[1,2-a]pyrimidine-3-carboxylates were prepared by reaction of ethyl 2-chloroacetoacetate with some 2-aminopyrimidines. These ethyl esters were then converted into the corresponding carboxylic acids via alkaline hydrolysis. The acids so obtained were evaluated for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.
摘要
通过2-氯乙酰乙酸乙酯与一些2-氨基嘧啶反应制备了一组2-甲基咪唑并[1,2-a]嘧啶-3-羧酸乙酯。然后通过碱性水解将这些乙酯转化为相应的羧酸。对如此得到的酸进行了抗炎、镇痛、解热和致溃疡活性评估。
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