血清甲胎蛋白可预测慢性丙型肝炎患者的治疗结果，无论其丙肝病毒基因型如何。
Serum alpha-fetoprotein predicts treatment outcome in chronic hepatitis C patients regardless of HCV genotype.
作者信息
Abdoul Hendy, Mallet Vincent, Pol Stanislas, Fontanet Arnaud
机构信息
Unité d'Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France.
出版信息
PLoS One. 2008 Jun 11;3(6):e2391. doi: 10.1371/journal.pone.0002391.
Abstract
We examined the association between serum alpha-fetoprotein (AFP) level and sustained virological response (SVR) in 93 chronic hepatitis C patients. The SVR rate was much higher among patients with serum AFP levels below rather than above the median value (5.7 ng/ml) (58.7% and 19.2%, respectively; P<0.0001). Serum AFP should be added to the list of factors predictive of treatment response in chronic hepatitis C.
摘要
我们检测了93例慢性丙型肝炎患者血清甲胎蛋白（AFP）水平与持续病毒学应答（SVR）之间的关联。血清AFP水平低于而非高于中位数（5.7 ng/ml）的患者，其SVR率要高得多（分别为58.7%和19.2%；P<0.0001）。血清AFP应列入慢性丙型肝炎治疗反应预测因素清单。
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