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利用数据挖掘分析白细胞介素28b基因多态性对慢性丙型肝炎4型感染埃及患者接受聚乙二醇化干扰素与利巴韦林联合治疗的病毒学应答的影响。

The impact of interleukin 28b gene polymorphism on the virological response to combined pegylated interferon and ribavirin therapy in chronic HCV genotype 4 infected egyptian patients using data mining analysis.

作者信息

Khairy Marwa, Fouad Rabab, Mabrouk Mahassen, El-Akel Wafaa, Awad Abu Bakr, Salama Rabab, Elnegouly Mayada, Shaker Olfat

机构信息

Endemic Medicine Department and Hepatology Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.

出版信息

Hepat Mon. 2013 Jul 17;13(7):e10509. doi: 10.5812/hepatmon.10509. eCollection 2013.

Abstract

BACKGROUND

Chronic HCV represents one of the common causes of chronic liver disease worldwide with Egypt having the highest prevalence, namely genotype 4. Interleukin IL-28B gene polymorphism has been shown to relate to HCV treatment response, mainly in genotype1.

OBJECTIVES

We aim to evaluate the predictive power of the rs12979860 IL28B SNP and its protein for treatment response in genotype 4 Egyptian patients by regression analysis and decision tree analysis.

PATIENTS AND METHODS

The study included 263 chronic HCV Egyptian patients receiving peg-interferon and ribavirin therapy. Patients were classified into 3 groups; non responders (83patients), relapsers (76patients) and sustained virological responders (104 patients). Serum IL 28 B was performed, DNA was extracted and analyzed by direct sequencing of the SNP rs 12979860 of IL28B gene.

RESULTS

CT, CC and TT represented 56 %, 25 % and 19% of the patients, respectively. Absence of C allele (TT genotype) was significantly correlated with the early failure of response while CC was associated with sustained virological response. The decision tree showed that baseline alpha fetoprotein (AFP ≤ 2.68 ng/ml) was the variable of initial split (the strongest predictor of response) confirmed by regression analysis. Patients with TT genotype had the highest probability of failure of response.

CONCLUSIONS

Absence of the C allele was significantly associated with failure of response. The presence of C allele was associated with a favorable outcome. AFP is a strong baseline predictor of HCV treatment response. A decision tree model is useful for predicting the probability of response to therapy.

摘要

背景

慢性丙型肝炎病毒(HCV)感染是全球慢性肝病的常见病因之一,埃及的患病率最高,主要为4型基因型。白细胞介素IL-28B基因多态性已被证明与HCV治疗反应相关,主要是在1型基因型中。

目的

我们旨在通过回归分析和决策树分析评估rs12979860 IL28B单核苷酸多态性(SNP)及其蛋白对4型埃及患者治疗反应的预测能力。

患者和方法

该研究纳入了263例接受聚乙二醇干扰素和利巴韦林治疗的慢性HCV感染埃及患者。患者分为3组:无反应者(83例)、复发者(76例)和持续病毒学应答者(104例)。检测血清IL-28B,提取DNA并通过对IL28B基因的SNP rs12979860进行直接测序进行分析。

结果

CT、CC和TT基因型分别占患者的56%、25%和19%。C等位基因缺失(TT基因型)与早期治疗反应失败显著相关,而CC基因型与持续病毒学应答相关。决策树显示,基线甲胎蛋白(AFP≤2.68 ng/ml)是初始划分的变量(最强的反应预测指标),回归分析证实了这一点。TT基因型患者治疗反应失败的概率最高。

结论

C等位基因缺失与治疗反应失败显著相关。C等位基因的存在与良好预后相关。AFP是HCV治疗反应的一个强有力的基线预测指标。决策树模型有助于预测治疗反应的概率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d379/3776149/07d7f4415210/hepatmon-13-07-10509-i001.jpg

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本文引用的文献

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