Beato Rogério, Levy Richard, Pillon Bernard, Vidal Christine, du Montcel Sophie Tezenas, Deweer Bernard, Bonnet Anne-Marie, Houeto Jean-Luc, Dubois Bruno, Cardoso Francisco
INSERM U610, Groupe Hospitalier de la Pitié-Salpêtrière, Paris, France.
Arq Neuropsiquiatr. 2008 Jun;66(2A):147-51. doi: 10.1590/s0004-282x2008000200001.
To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM.
The paradigm was based on the 'n-back' tasks, which enables to study the level of executive demand (three levels of difficulty) and the domain of the information being processed (spatial items, faces and letters). The effect of levodopa was studied by testing PD patients in "on" and "off" states.
PD patients performed less well in WM tasks than controls. There was no interaction between groups and complexity. Levodopa therapy had a positive effect only on spatial WM tasks but no effect on complexity.
Our results suggest that impairment observed may result from a maintenance deficit within WM regardless the level of processing and levodopa therapy presents a positive effect on spatial WM.
评估帕金森病（PD）患者工作记忆（WM）的临床特征，并测试左旋多巴对WM的影响。
该范式基于“n-back”任务，能够研究执行需求水平（三个难度级别）以及所处理信息的领域（空间项目、面部和字母）。通过在“开”和“关”状态下测试PD患者来研究左旋多巴的效果。
PD患者在WM任务中的表现不如对照组。组间与任务复杂性之间没有交互作用。左旋多巴治疗仅对空间WM任务有积极影响，对任务复杂性无影响。
我们的结果表明，观察到的损伤可能是由于WM内的维持缺陷导致的，而与处理水平无关，并且左旋多巴治疗对空间WM有积极影响。
