Manzoni Gian Camillo, Torelli Paola
Headache Centre, Section of Neurology, Department of Neuroscience, University of Parma, c/o Ospedale Maggiore, Via Gramsci 14, 43100 Parma, Italy.
Neurol Sci. 2008 May;29 Suppl 1:S40-3. doi: 10.1007/s10072-008-0884-7.
A debate has been going on for many years about whether migraine with aura and migraine without aura are part of the same disorder or should instead be considered as two separate disorders. Although no final consensus has yet been reached on this issue, many clinical and pathogenetic elements suggest that the second option is true. Clinically, migraine with aura and migraine without aura are differentiated by epidemiological features, the characteristics of the headache phase, patient behaviour during attacks, natural history, age at onset and age at resolution, the recurrence pattern of attacks, favouring circumstances and trigger factors, correlation to female reproductive events, comorbidity and preventive therapies. Moreover, several literature reports suggest a possible different pathogenetic basis for the two forms of migraine.
关于伴有先兆的偏头痛和不伴有先兆的偏头痛是同一疾病的一部分，还是应被视为两种不同的疾病，这场争论已经持续多年。尽管在这个问题上尚未达成最终共识，但许多临床和发病机制方面的因素表明第二种观点是正确的。在临床上，伴有先兆的偏头痛和不伴有先兆的偏头痛可通过流行病学特征、头痛期的特点、发作时患者的行为、自然病史、发病年龄和缓解年龄、发作的复发模式、诱发情况和触发因素、与女性生殖事件的相关性、合并症及预防性治疗来区分。此外，一些文献报告表明这两种偏头痛形式可能存在不同的发病机制基础。
