Scambia G, Benedetti P, Ferrandina G, Battaglia F, Baiocchi G, Mancuso S
Department of Gynecology, Catholic University, Rome, Italy.
Br J Cancer. 1991 Jul;64(1):182-4. doi: 10.1038/bjc.1991.266.
Using an immunoradiometric assay, Cathepsin-D (Cath-D) concentrations were measured in the cytosol of 68 normal and neoplastic human ovarian tissues. Cath-D levels were higher in malignant tumours than in normal tissue samples (P less than 0.01) and benign tumours (P less than 0.01). In six out of seven cases, metastatic deposits showed Cath-D concentrations higher than the respective primary tumours. Using 12 of 17 pmols.mg-1 protein as cut-off levels, the Cath-D status (high or low) was not related to any pathological parameter. Moreover, no correlation was found between Cath-D levels and receptors for oestrogen, progesterone and epidermal growth factor. Our results indicate that ovarian tumours produce Cath-D. Further studies are needed to evaluate whether this protein could represent a prognostic factor for this neoplasia.
采用免疫放射分析方法，测定了68例正常和肿瘤性人卵巢组织胞浆中组织蛋白酶D（Cath-D）的浓度。恶性肿瘤中的Cath-D水平高于正常组织样本（P<0.01）和良性肿瘤（P<0.01）。在7例中的6例中，转移灶的Cath-D浓度高于各自的原发肿瘤。以17 pmols.mg-1蛋白质中的12个作为临界水平，Cath-D状态（高或低）与任何病理参数均无关联。此外，未发现Cath-D水平与雌激素、孕激素和表皮生长因子受体之间存在相关性。我们的结果表明卵巢肿瘤会产生Cath-D。需要进一步研究以评估这种蛋白质是否可能代表这种肿瘤的一个预后因素。
