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在MRI研究扫描中寻找偶发发现的风险与益处。

The risks and benefits of searching for incidental findings in MRI research scans.

作者信息

Royal Jason M, Peterson Bradley S

机构信息

City University of New York, USA.

出版信息

J Law Med Ethics. 2008 Summer;36(2):305-14, 212. doi: 10.1111/j.1748-720X.2008.00274.x.

DOI:10.1111/j.1748-720X.2008.00274.x
PMID:18547199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4290840/
Abstract

We weigh the presumed benefits of routinely searching all research scans for incidental findings (IFs) against its substantial risks, including false-positive and false-negative findings, and the possibility of triggering unnecessary, costly evaluations and perhaps harmful treatments. We argue that routinely searching for IFs may not maximize benefits and minimize risks to participants.

摘要

我们权衡了对所有研究扫描结果进行常规筛查以发现偶发疾病(IFs)的假定益处与其重大风险,包括假阳性和假阴性结果,以及引发不必要的、昂贵的评估乃至可能有害治疗的可能性。我们认为,常规筛查偶发疾病可能无法使参与者的益处最大化且风险最小化。

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Ethics. Incidental findings in brain imaging research.伦理学。脑成像研究中的偶发发现。
Science. 2006 Feb 10;311(5762):783-4. doi: 10.1126/science.1124665.
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Discovery and disclosure of incidental findings in neuroimaging research.神经影像学研究中偶然发现的发现与披露。
J Magn Reson Imaging. 2004 Nov;20(5):743-7. doi: 10.1002/jmri.20180.
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Neurology. 2004 Mar 23;62(6):888-90. doi: 10.1212/01.wnl.0000118531.90418.89.
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