铜离子-ATP酶制动系统。
Cu+ -ATPases brake system.
作者信息
Argüello José M, González-Guerrero Manuel
出版信息
Structure. 2008 Jun;16(6):833-4. doi: 10.1016/j.str.2008.05.002.
PMID:18547514
Abstract
Copper (Cu+) transport ATPases are characterized by cytoplasmic metal-binding repeats. Using cryo-electron microscopy (cryo-EM) of functionally intact Cu+-ATPases and high-resolution structures of isolated domains, Wu et al. (2008) produced a model that explains how Cu+ binding to cytoplasmic sites controls the enzyme transport rate.
摘要
铜（Cu+）转运ATP酶的特征是具有胞质金属结合重复序列。通过对功能完整的Cu+ -ATP酶进行冷冻电子显微镜（cryo-EM）观察以及对分离结构域的高分辨率结构分析，吴等人（2008年）构建了一个模型，该模型解释了Cu+与胞质位点的结合如何控制酶的转运速率。
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