Calvert George T, Devane Peter A, Fielden Jan, Adams Kathryn, Horne J Geoffrey
Department of Surgery, Division of Orthopedic Surgery, Wellington School of Medicine, Wellington, New Zealand.
J Arthroplasty. 2009 Jun;24(4):505-10. doi: 10.1016/j.arth.2008.02.011. Epub 2008 Jun 10.
Highly cross-linked polyethylene was developed to reduce articular bearing wear in total hip arthroplasty. In vitro studies have shown reduced wear in comparison with conventional polyethylene. A double-blind, prospective, randomized trial was performed comparing highly cross-linked and conventional polyethylene in 119 patients. The primary outcome variables were linear, 3-dimensional, and volumetric wear as determined by analysis of digitized radiographs using validated wear measurement software. Linear, 3-dimensional, and volumetric wear rates were significantly less in the highly cross-linked polyethylene group between 6 months and 4 years postoperatively (P < .05). The data presented here show that highly cross-linked polyethylene reduces short-term polyethylene wear. The intermediate and long-term clinical results of highly cross-linked polyethylene remain unknown pending further follow-up.
高度交联聚乙烯的研发旨在减少全髋关节置换术中关节轴承的磨损。体外研究表明，与传统聚乙烯相比，其磨损有所减少。对119例患者进行了一项双盲、前瞻性、随机试验，比较高度交联聚乙烯和传统聚乙烯。主要结局变量是通过使用经过验证的磨损测量软件分析数字化X线片确定的线性、三维和体积磨损。术后6个月至4年，高度交联聚乙烯组的线性、三维和体积磨损率显著更低（P < 0.05）。此处呈现的数据表明，高度交联聚乙烯可减少聚乙烯的短期磨损。高度交联聚乙烯的中长期临床结果在进一步随访之前仍未知。
