（-）-表没食子儿茶素-3-O-没食子酸脂肪酸单酯衍生物增强的抗甲型流感病毒活性：烷基链长度的影响
Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length.
作者信息
Mori Shuichi, Miyake Shinya, Kobe Takayoshi, Nakaya Takaaki, Fuller Stephen D, Kato Nobuo, Kaihatsu Kunihiro
机构信息
The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
出版信息
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4249-52. doi: 10.1016/j.bmcl.2008.02.020. Epub 2008 Feb 10.
PMID:18547804
Abstract
A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG.
摘要
通过一锅法脂肪酶催化的酯交换反应制备了一系列（-）-表没食子儿茶素-3-O-没食子酸酯（EGCG）的脂肪酸单酯衍生物。与天然EGCG相比，长烷基链的引入使抗甲型流感病毒A/PR8/34（H1N1）活性提高了24倍。
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