May K, Becker C M
Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Minerva Ginecol. 2008 Jun;60(3):245-54.
Endometriosis is a common gynecological condition, responsible for significant morbidity and social-economic impact. Although the condition has been recognized for many years, the underlying pathophysiology is poorly understood. In turn, this results in inadequate treatment and high recurrence rates. Various theories try to explain the presence of endometrial tissue outside the uterine cavity. However, none of them can explain all disease locations and appearances, and it is unclear how these fragments establish into endometriotic lesions. New vessel formation has long been recognized as a feature of endometriosis, often clearly visible at laparoscopy. Recent work has focused on identifying the role of vascularization in the pathogenesis of endometriosis, by allowing lesions to establish and grow. In this review the authors outline the basic mechanisms of angiogenesis and vasculogenesis in the human eutopic endometrium, and consider how this data can be applied to endometriotic implants. Furthermore, the authors discuss molecular mechanisms of angiogenesis and vasculogenesis, and how this may be used to therapeutic advantage in the treatment of endometriosis.
子宫内膜异位症是一种常见的妇科疾病，会导致严重的发病率以及社会经济影响。尽管该疾病已被认识多年，但其潜在的病理生理学仍知之甚少。相应地，这导致了治疗不足和高复发率。各种理论试图解释子宫腔外子宫内膜组织的存在。然而，它们都无法解释所有的疾病部位和表现，并且尚不清楚这些碎片是如何形成子宫内膜异位病变的。新血管形成长期以来一直被认为是子宫内膜异位症的一个特征，在腹腔镜检查时通常清晰可见。最近的研究工作集中在通过允许病变形成和生长来确定血管生成在子宫内膜异位症发病机制中的作用。在这篇综述中，作者概述了人在位子宫内膜中血管生成和血管发生的基本机制，并考虑如何将这些数据应用于子宫内膜异位植入物。此外，作者讨论了血管生成和血管发生的分子机制，以及这如何在子宫内膜异位症的治疗中用于治疗优势。
