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本文引用的文献

1
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.鉴定ATP酶pontin和reptin为端粒酶全酶组装所必需的组分。
Cell. 2008 Mar 21;132(6):945-57. doi: 10.1016/j.cell.2008.01.019.
2
A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly.前体小分子核仁核糖核蛋白（snoRNP）因子的动态支架促进人C/D盒snoRNP组装。
Mol Cell Biol. 2007 Oct;27(19):6782-93. doi: 10.1128/MCB.01097-07. Epub 2007 Jul 16.
3
Control of transcription by Pontin and Reptin.庞廷蛋白和雷廷蛋白对转录的调控
Trends Cell Biol. 2007 Apr;17(4):187-92. doi: 10.1016/j.tcb.2007.02.005. Epub 2007 Feb 22.
4
Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases.三种酵母RNA聚合酶共有的Rpb5亚基的功能组织
Nucleic Acids Res. 2007;35(2):634-47. doi: 10.1093/nar/gkl686. Epub 2006 Dec 19.
5
New insights into nucleolar architecture and activity.对核仁结构与活性的新见解。
Int Rev Cytol. 2006;255:177-235. doi: 10.1016/S0074-7696(06)55004-1.
6
TFF3-peptide increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression.三叶因子3肽通过调节闭合蛋白-1和-2的表达来增加上皮细胞的跨上皮电阻。
Peptides. 2006 Dec;27(12):3383-90. doi: 10.1016/j.peptides.2006.08.020. Epub 2006 Oct 2.
7
The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity.组氨酸三联体蛋白Hint1可独立于其酶活性触发细胞凋亡。
J Biol Chem. 2006 Sep 15;281(37):27356-66. doi: 10.1074/jbc.M513452200. Epub 2006 Jul 11.
8
Structure and function of the nucleolus in the spotlight.备受瞩目的核仁的结构与功能
Curr Opin Cell Biol. 2006 Jun;18(3):325-34. doi: 10.1016/j.ceb.2006.04.008. Epub 2006 May 9.
9
NOPdb: Nucleolar Proteome Database.NOPdb：核仁蛋白质组数据库。
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D218-20. doi: 10.1093/nar/gkj004.
10
Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.Myc在果蝇发育过程中与Tip48/Reptin和Tip49/Pontin发生遗传相互作用，以控制生长和增殖。
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11799-804. doi: 10.1073/pnas.0408945102. Epub 2005 Aug 8.

Pontin定位于核仁纤维中心。

Pontin is localized in nucleolar fibrillar centers.

作者信息

Cvacková Zuzana, Albring Kai F, Koberna Karel, Ligasová Anna, Huber Otmar, Raska Ivan, Stanek David

机构信息

Institute of Cellular Biology and Pathology, 1st Faculty of Medicine, Charles University in Prague, Albertov 4, 128 00 Prague 2, Czech Republic.

出版信息

Chromosoma. 2008 Oct;117(5):487-97. doi: 10.1007/s00412-008-0170-8. Epub 2008 Jun 12.

DOI:10.1007/s00412-008-0170-8
PMID:18548265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2564108/
Abstract

Pontin is a multifunctional protein having roles in various cellular processes including regulation of gene expression. Here, we addressed Pontin intracellular localization using two different monoclonal antibodies directed against different Pontin epitopes. For the first time, Pontin was directly visualized in nucleoli where it co-localizes with Upstream Binding Factor and RNA polymerase I. Nucleolar localization of Pontin was confirmed by its detection in nucleolar extracts and by electron microscopy, which revealed Pontin accumulation specifically in the nucleolar fibrillar centers. Pontin localization in the nucleolus was dynamic and Pontin accumulated in large nucleolar dots mainly during S-phase. Pontin concentration in the large nucleolar dots correlated with reduced transcriptional activity of nucleoli. In addition, Pontin was found to associate with RNA polymerase I and to interact in a complex with c-Myc with rDNA sequences indicating that Pontin is involved in the c-Myc-dependent regulation of rRNA synthesis.

摘要

Pontin是一种多功能蛋白质，在包括基因表达调控在内的各种细胞过程中发挥作用。在此，我们使用两种针对不同Pontin表位的不同单克隆抗体研究了Pontin在细胞内的定位。首次在核仁中直接观察到Pontin，它与上游结合因子和RNA聚合酶I共定位。通过在核仁提取物中的检测以及电子显微镜观察证实了Pontin在核仁中的定位，电子显微镜显示Pontin特异性积聚在核仁纤维中心。Pontin在核仁中的定位是动态的，并且Pontin主要在S期积聚在大的核仁点中。大核仁点中的Pontin浓度与核仁转录活性降低相关。此外，发现Pontin与RNA聚合酶I相关，并与c-Myc在一个与rDNA序列形成的复合物中相互作用，表明Pontin参与了c-Myc依赖的rRNA合成调控。