内脏激素和神经肽对胆管细胞适应性反应的调控
Control of cholangiocyte adaptive responses by visceral hormones and neuropeptides.
作者信息
Marzioni Marco, Fava Giammarco, Alvaro Domenico, Alpini Gianfranco, Benedetti Antonio
机构信息
Department of Gastroenterology, Università Politecnica delle Miarche, Nuovo Polo Didattico, III piano, Via Tronto 10, 60020, Ancona, Italy.
出版信息
Clin Rev Allergy Immunol. 2009 Feb;36(1):13-22. doi: 10.1007/s12016-008-8090-1.
Abstract
Cholangiocytes, the epithelial cells lining the biliary tree, are the target cells in several liver diseases, termed cholangiopathies. Cholangiopathies are a challenge for clinicians and an enigma for scientists, as the pathogenetic mechanisms by which they develop, and the therapeutic tools for these diseases are still undefined. Several studies demonstrate that many visceral hormones, neuropeptides, and neurotransmitters modulate the adaptive changes of cholangiocytes to chronic cholestatic injury. The aim of this review is to present the recent findings that contributed to clarify the role of visceral hormones and neuropeptides in the regulation of the pathophysiology of cholestasis. These studies helped to shed light on some aspects of cholangiocyte pathophysiology, revealing novel perspectives for the clinical managements of cholangiopathies.
摘要
胆管细胞是胆管树内衬的上皮细胞，是几种肝脏疾病（称为胆管病）中的靶细胞。胆管病对临床医生来说是一项挑战，对科学家来说是一个谜，因为它们的发病机制以及针对这些疾病的治疗工具仍不明确。多项研究表明，许多内脏激素、神经肽和神经递质可调节胆管细胞对慢性胆汁淤积性损伤的适应性变化。本综述的目的是介绍最近的研究结果，这些结果有助于阐明内脏激素和神经肽在胆汁淤积病理生理学调节中的作用。这些研究有助于阐明胆管细胞病理生理学的某些方面，为胆管病的临床管理揭示了新的视角。
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