Martinez M, Ausejo M, Miguel J L, Gonzalez M L, Balaguer G, Catalan P, Selgas R
Biochemistry and Nephrology Service, Hospital La Paz Madrid, Spain.
Perit Dial Int. 1991;11(2):137-40.
Twenty-nine patients on hemodialysis (HD) and 29 patients on continuous ambulatory peritoneal dialysis (CAPD) were studied. Serum calcium and phosphorous levels were similar in the 2 groups. Serum parathyroid hormone (PTH) levels were determined by 4 different methods. Mid-molecule PTH levels were higher in HD (1099.5 +/- 876.8 pmol/L) than in CAPD patients (541.0 +/- 138.8 pmol/L), p less than 0.001, while intact PTH levels were similar. The ratio MM-PTH/Intact PTH was higher in HD (55.2 +/- 29.0) than in CAPD patients (39.0 +/- 20.0), where p less than 0.01. In patients with similar C-PTH, those on CAPD had higher levels of intact PTH (46.0 +/- 27.0 pmol/L) than those in HD (29.3 +/- 29.0 pmol/L), p less than 0.01. The ratio C-PTH/intact PTH was higher in HD (104.9 +/- 39.6) than in CAPD patients (59.3 +/- 32.3), p less than 0.001. The Peritoneal Saturation Index (PSI) of MM-PTH was 23.4 +/- 12%, and it showed a hyperbolic correlation in respect to MM-PTH serum levels. We concluded that CAPD can modify the plasma C-PTH and MM-PTH serum levels by peritoneal losses of these fragments.
对29例血液透析（HD）患者和29例持续性非卧床腹膜透析（CAPD）患者进行了研究。两组患者的血清钙和磷水平相似。采用4种不同方法测定血清甲状旁腺激素（PTH）水平。HD患者的中分子PTH水平（1099.5±876.8 pmol/L）高于CAPD患者（541.0±138.8 pmol/L），p<0.001，而完整PTH水平相似。HD患者的MM-PTH/完整PTH比值（55.2±29.0）高于CAPD患者（39.0±20.0），p<0.01。在C-PTH水平相似的患者中，CAPD患者的完整PTH水平（46.0±27.0 pmol/L）高于HD患者（29.3±29.0 pmol/L），p<0.01。HD患者的C-PTH/完整PTH比值（104.9±39.6）高于CAPD患者（59.3±32.3），p<0.001。MM-PTH的腹膜饱和指数（PSI）为23.4±12%，且与MM-PTH血清水平呈双曲线相关。我们得出结论，CAPD可通过这些片段的腹膜丢失来改变血浆C-PTH和MM-PTH血清水平。
