Jensen P B, Rasmussen H B, Pedersen F B
Department of Nephrology, Odense University Hospital, Denmark.
APMIS. 1997 May;105(5):371-7. doi: 10.1111/j.1699-0463.1997.tb00583.x.
Using an ELISA technique, the aminopropeptide of type I procollagen (PINP) was measured in serum from patients with chronic renal failure treated with haemodialysis (HD) (n = 19) or continuous ambulatory peritoneal dialysis (CAPD) (n = 14), and compared to the commonly used bone markers. The serum concentrations for PINP, compared to healthy controls were significantly increased in both the HD-group (p < 0.00001) and the CAPD-group (p < 0.00001). In the HD-group a close correlation was found between PINP and parathyroid hormone (PTH) (R(s) = 0.745; p = 0.00026) and between PINP and total alkaline phosphatase (R(s) = 0.623; p = 0.004), but in the CAPD-group the corresponding p-values were 0.17 and 0.06 only. No significant difference was found between the HD and CAPD patients with respect to serum levels of PINP, PTH, total alkaline phosphatase, or ionized calcium. In the HD-patients, a significantly higher level of serum phosphate was found compared to in the CAPD-patients. The present study demonstrates a close correlation between PTH, total alkaline phosphatase and PINP, which indicates that PINP might be used as a marker for evaluating increased bone turnover in patients with chronic renal failure treated with haemodialysis, and perhaps also in patients treated with peritoneal dialysis, and that the ideal biochemical parameters to analyse changes in bone metabolism in these patients may be a combination of the initiating hormone (PTH) and PINP as a marker of the effect of PTH on bone metabolism.
采用酶联免疫吸附测定（ELISA）技术，对接受血液透析（HD）治疗的慢性肾衰竭患者（n = 19）和持续性非卧床腹膜透析（CAPD）患者（n = 14）的血清中I型前胶原氨基端前肽（PINP）进行检测，并与常用的骨标志物进行比较。与健康对照组相比，HD组（p < 0.00001）和CAPD组（p < 0.00001）的血清PINP浓度均显著升高。在HD组中，PINP与甲状旁腺激素（PTH）之间存在密切相关性（R(s) = 0.745；p = 0.00026），与总碱性磷酸酶之间也存在密切相关性（R(s) = 0.623；p = 0.004），但在CAPD组中，相应的p值分别仅为0.17和0.06。HD患者和CAPD患者在血清PINP、PTH、总碱性磷酸酶或离子钙水平方面未发现显著差异。与CAPD患者相比，HD患者的血清磷酸盐水平显著更高。本研究表明PTH、总碱性磷酸酶和PINP之间存在密切相关性，这表明PINP可能用作评估接受血液透析治疗的慢性肾衰竭患者骨转换增加的标志物，或许也可用于评估接受腹膜透析治疗的患者，并且分析这些患者骨代谢变化的理想生化参数可能是起始激素（PTH）和作为PTH对骨代谢影响标志物的PINP的组合。
