Franz N, Modersohn D, Romaniuk P, Linss G
Klinik für Innere Medizin, Humboldt-Universität zu Berlin und Klinikum Berlin-Buch.
Z Gesamte Inn Med. 1991 Jan-Feb;46(1-2):15-7.
In 40 male coronary patients during heart catheterization the coronary flow reserve was investigated by continuous thermodilution in the coronary sinus after intracoronary papaverine application. Simultaneously a number of heart function parameters were recorded. Already the lowest dosage of papaverine (5 mg) was able to induce a maximal flow acceleration. Higher dosages were accompanied with haemodynamic side effects (increase of heart rate and left ventricular end-diastolic pressure, decrease of left ventricular systolic pressure, appearance of myocardial ischemia) without further increase of coronary flow. After at most 5 minutes time the papaverine effects completely disappeared. In conclusion, a safe, short-lasting and repeatable determination of the coronary flow reserve (for instance during PTCA) proved to be possible after intracoronary papaverine injection in low dosages (5 mg).
在40例接受心脏导管插入术的男性冠心病患者中，在冠状动脉内应用罂粟碱后，通过冠状动脉窦连续热稀释法研究冠状动脉血流储备。同时记录了一些心功能参数。即使是最低剂量的罂粟碱（5毫克）也能够引起最大的血流加速。更高剂量伴随着血流动力学副作用（心率增加、左心室舒张末期压力升高、左心室收缩压降低、心肌缺血出现），而冠状动脉血流并未进一步增加。最多5分钟后，罂粟碱的作用完全消失。总之，低剂量（5毫克）冠状动脉内注射罂粟碱后，证明有可能安全、短暂且可重复地测定冠状动脉血流储备（例如在经皮冠状动脉腔内血管成形术期间）。
