Karpova V V, Tverskaia M S, Virganskiĭ A O, Banin V V, Tikhvinskaia E I, Satylganov I Zh, Chumakova M A, Rogulenko R V
Biull Eksp Biol Med. 1991 Feb;111(2):130-2.
A comparative study of hemodynamic and structural-metabolic changes in the myocardium of the right (RV) and left ventricles (LV) in acute massive pulmonary artery embolism was made in 19 mongrel dogs. In the control group the activity of SDH, MDH, GDH, NADH-DH in LV were higher than in RV. The numeral density and relative area of mitochondrial profile surface in LV was higher that in RV. A significant increase in afterload on RV causes intensification of cell respiration, a rise in numeral density and relative area of mitochondrial profile surface. Weakening of LV work leads to contrary structural-metabolic changes. Thus, contrary changes in hemodynamic loads on RV and LV in acute compensative massive pulmonary artery embolism correlated with contrary changes in their cell metabolism.
对19只杂种犬进行了急性大面积肺动脉栓塞时右心室（RV）和左心室（LV）心肌血流动力学及结构代谢变化的比较研究。对照组中，LV的SDH、MDH、GDH、NADH - DH活性高于RV。LV线粒体轮廓表面的数字密度和相对面积高于RV。RV后负荷的显著增加导致细胞呼吸增强，线粒体轮廓表面的数字密度和相对面积增加。LV工作减弱导致相反的结构代谢变化。因此，急性代偿性大面积肺动脉栓塞时RV和LV血流动力学负荷的相反变化与其细胞代谢的相反变化相关。
