Zhdanova I V, Kordzadze R N, Pliashkevich Iu G
Biull Eksp Biol Med. 1991 Feb;111(2):165-8.
It is shown that suboccipital injection of 100 micrograms of the gexapeptide GLLDLK (the fragment of endogenous peptide--the inhibitor of diazepam binding) modified (for 1-3 days) the emotionally conditioned behaviour of the rats (the test of "emotional resonance"). This modification was realized in some reinforcement of different behavioural patterns and had signs of anxiety and depression. In the test "social hierarchy" the injection of GLLDLK didn't change significantly the hierarchy in the whole rat society, but in the recipient behaviour the exploratory activity has been changed, the time of grooming increased and the quantity of social contacts decreased.
结果表明，枕下注射100微克的gexapeptide GLLDLK（内源性肽片段——地西泮结合抑制剂）可在1至3天内改变大鼠的情绪条件行为（“情绪共鸣”测试）。这种改变表现为不同行为模式的某种强化，并有焦虑和抑郁的迹象。在“社会等级”测试中，注射GLLDLK并没有显著改变整个大鼠群体的等级制度，但在接受者的行为方面，探索活动发生了变化，梳理毛发的时间增加，社交接触的数量减少。
