[黑质在药理点燃过程中地西泮的抗惊厥和抗攻击作用中的作用]

[The role of the substantia nigra in the anticonvulsive and antiaggressive effects of diazepam during pharmacological kindling].

作者信息

Shandra A A, Godlevskiĭ L S, Mazarati A M, Makul'kin R F

出版信息

Neirofiziologiia. 1990;22(4):482-5.

Abstract

The seizure activity was investigated on the model of pharmacological kindling which was induced by repeated picrotoxin injections in the subthreshold dose, after the tryptic fragment of T5 protein-human diazepam binding inhibitor (DBI) (10 micrograms) injection into a reticular part of substantia nigra. An increase in the seizure reaction and suppression of the antiseizure diazepam action were observed. Intranigral DBI injection induced no change in a threshold of "attacks" in rats which were induced through electric shocks delivered to animals with an electrode floor and no changes in antiaggressive diazepam action were observed under such conditions.

摘要

在亚阈值剂量下反复注射苦味毒诱导的药理学点燃模型上，研究癫痫发作活动。将T5蛋白-人地西泮结合抑制剂（DBI）的胰蛋白酶片段（10微克）注射到黑质网状部后，观察到癫痫反应增强以及抗癫痫药物地西泮作用受到抑制。在通过置于动物地板上的电极施加电击诱导大鼠“发作”的情况下，向黑质内注射DBI未引起“发作”阈值的变化，并且在此条件下未观察到地西泮抗攻击作用的改变。

相似文献

1

[The role of the substantia nigra in the anticonvulsive and antiaggressive effects of diazepam during pharmacological kindling].[黑质在药理点燃过程中地西泮的抗惊厥和抗攻击作用中的作用]

Neirofiziologiia. 1990;22(4):482-5.

2

[The role of the opiate mechanisms of the hippocampus and substantia nigra in the behavioral and convulsive disorders in picrotoxin-induced kindling].[海马体和黑质的阿片类机制在匹鲁卡品诱导点燃模型的行为和惊厥障碍中的作用]

Biull Eksp Biol Med. 1991 Mar;111(3):235-9.

3

[The effect of the cerebrospinal fluid from rats subjected to picrotoxin-induced kindling on the motor activity and seizure susceptibility of recipient animals].[匹鲁卡品诱导点燃大鼠的脑脊液对受体动物运动活动和癫痫易感性的影响]

Fiziol Zh (1978). 1991 Mar-Apr;37(2):7-11.

4

[The anticonvulsive action of the intranigral administration of the delta sleep-inducing peptide].[经黑质内注射δ-睡眠诱导肽的抗惊厥作用]

Fiziol Zh (1978). 1992 Jul-Aug;38(4):27-32.

5

Effect of diazepam and medazepam on pentylenetetrazol kindling in albino rats.地西泮和去甲西泮对白化大鼠戊四氮点燃效应的影响。

Acta Physiol Pharmacol Bulg. 1990;16(2):37-41.

6

Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.有证据表明α-2肾上腺素能受体参与黑质内注射蝇蕈醇的抗惊厥作用。

J Pharmacol Exp Ther. 1987 Jun;241(3):751-4.

7

[Effects of diazepam and N(6)-cyclohexyladenosine on the level of diazepam-binding inhibitor in structures of the hippocampus during immobilization stress].[地西泮和N(6)-环己基腺苷对固定应激期间海马结构中地西泮结合抑制剂水平的影响]

Biull Eksp Biol Med. 1990 Aug;110(8):166-7.

8

Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy.癫痫点燃模型中假定的黑质γ-氨基丁酸能神经元放电率、模式及药物敏感性的亚区变化

Eur J Neurosci. 2004 Nov;20(9):2377-86. doi: 10.1111/j.1460-9568.2004.03699.x.

9

Bilateral microinjection of ethosuximide into the substantia nigra does not prevent amygdala-kindled seizures.

Braz J Med Biol Res. 1990;23(11):1139-41.

10

Effect of microinjections of gamma-vinyl GABA or isoniazid into substantia nigra on the development of amygdala kindling in rats.向大鼠黑质微量注射γ-乙烯基γ-氨基丁酸或异烟肼对杏仁核点燃发展的影响。

Exp Neurol. 1987 Mar;95(3):622-38. doi: 10.1016/0014-4886(87)90304-9.

引用本文的文献

1

Effect of intranigral dosage with delta-sleep-inducing peptide and its analogs on movement and convulsive activity in rats.

Neurosci Behav Physiol. 1996 Nov-Dec;26(6):567-71. doi: 10.1007/BF02359501.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。