Shandra A A, Godlevskiĭ L S, Mazarati A M, Makul'kin R F
Neirofiziologiia. 1990;22(4):482-5.
The seizure activity was investigated on the model of pharmacological kindling which was induced by repeated picrotoxin injections in the subthreshold dose, after the tryptic fragment of T5 protein-human diazepam binding inhibitor (DBI) (10 micrograms) injection into a reticular part of substantia nigra. An increase in the seizure reaction and suppression of the antiseizure diazepam action were observed. Intranigral DBI injection induced no change in a threshold of "attacks" in rats which were induced through electric shocks delivered to animals with an electrode floor and no changes in antiaggressive diazepam action were observed under such conditions.
在亚阈值剂量下反复注射苦味毒诱导的药理学点燃模型上，研究癫痫发作活动。将T5蛋白-人地西泮结合抑制剂（DBI）的胰蛋白酶片段（10微克）注射到黑质网状部后，观察到癫痫反应增强以及抗癫痫药物地西泮作用受到抑制。在通过置于动物地板上的电极施加电击诱导大鼠“发作”的情况下，向黑质内注射DBI未引起“发作”阈值的变化，并且在此条件下未观察到地西泮抗攻击作用的改变。
