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[The resistance of in vivo selected tumor cells of malignant phenotype to the cytolytic action of activated peritoneal macrophages in vitro].

作者信息

Vol'pe E A

出版信息

Biull Eksp Biol Med. 1991 Feb;111(2):177-9.

PMID:1854964
Abstract

Using radioisotope cytolytic 3H-thymidine release assay the sensitivity of low-malignant spontaneously in vitro transformed hamster embryo cells (STHE strain) and its in vivo selected malignant variants (STHE-LM-4, STHE-LM-8, STHE-75/18) as well as Rous sarcoma virus (RSV) (Schmidt-Ruppin strain) tumorigenic transformants (HET-SR-1, TU-SR) were tested to cytolysis by peritoneal Syrian hamster macrophages (MP) activated in vitro with levan, LPS, MDP and PMA. It has been shown that the only parental cells STHE strain (non-selected in vivo) were sensitive to cytolysis by activated MP. All in vivo selected malignant variants of STHE cell sublines as well as tumorigenic RSV-SR-transformants were resistant to cytolysis by activated MP. Thioglycollate-elicited but not activated MP did not destroy any tumour target cells.

摘要

相似文献

1
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Biull Eksp Biol Med. 1991 Feb;111(2):177-9.
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引用本文的文献

1
Resistance of in vivo-selected spontaneously transformed cells and Rous sarcoma virus-transformed cells to macrophage-mediated cytotoxicity.体内选择的自发转化细胞和劳氏肉瘤病毒转化细胞对巨噬细胞介导的细胞毒性的抗性。
Experientia. 1992 May 15;48(5):500-3. doi: 10.1007/BF01928174.