Shibata Rei, Numaguchi Yasushi, Matsushita Kunihiro, Sone Takahito, Kubota Ryuji, Ohashi Taiki, Ishii Masakazu, Kihara Shinji, Walsh Kenneth, Ouchi Noriyuki, Murohara Toyoaki
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Am J Cardiol. 2008 Jun 15;101(12):1712-5. doi: 10.1016/j.amjcard.2008.02.057. Epub 2008 Apr 9.
Adiponectin is an adipose-derived plasma protein that demonstrates beneficial actions on myocardial injury under ischemic conditions. Circulating endothelial progenitor cells are reported to associate with rescue of cardiac damage after acute myocardial infarction (AMI). We examined whether circulating adiponectin level affects myocardial function and injury in patients with AMI. A total of 48 patients who underwent successful reperfusion treatment after AMI were enrolled. Cardiac function and perfusion defect were assessed by scintigraphic images of iodine-123 beta-methyl iodophenyl pentadecanoic acid in the acute phase and technetium-99m tetrofosmin in the long-term phase. Plasma adiponectin levels were measured by enzyme-linked immunosorbent assay at day 7 after AMI. Plasma adiponectin levels associated positively with myocardial salvage index representing the proportion of initial perfusion defect rescued by reperfusion and recovery of ejection fraction in the long-term phase and negatively with final infarct size. A positive correlation was also observed between adiponectin levels and number of circulating CD34(+) cells as determined by flow cytometry and between myocardial salvage index and recovery of ejection fraction independently associated with circulating CD34(+) cell levels. In conclusion, plasma adiponectin levels predict improvement of cardiac damage and function after reperfusion therapy in patients with AMI, suggesting that adiponectin could serve as a biomarker for assessment of myocardial injury after AMI.
脂联素是一种源自脂肪组织的血浆蛋白，在缺血条件下对心肌损伤具有有益作用。据报道，循环内皮祖细胞与急性心肌梗死（AMI）后心脏损伤的挽救有关。我们研究了循环脂联素水平是否会影响AMI患者的心肌功能和损伤。共纳入48例AMI后接受成功再灌注治疗的患者。在急性期通过碘-123β-甲基碘苯基十五烷酸闪烁图像以及在长期阶段通过锝-99m替曲膦闪烁图像评估心脏功能和灌注缺损。在AMI后第7天通过酶联免疫吸附测定法测量血浆脂联素水平。血浆脂联素水平与心肌挽救指数呈正相关，心肌挽救指数代表再灌注挽救的初始灌注缺损比例以及长期阶段射血分数的恢复情况，且与最终梗死面积呈负相关。通过流式细胞术测定，脂联素水平与循环CD34(+)细胞数量之间也观察到正相关，并且心肌挽救指数与射血分数的恢复情况独立于循环CD34(+)细胞水平相关。总之，血浆脂联素水平可预测AMI患者再灌注治疗后心脏损伤和功能的改善情况，提示脂联素可作为评估AMI后心肌损伤的生物标志物。
