复发性自然流产女性的血小板衍生微粒水平
Platelet-derived microparticle levels in women with recurrent spontaneous abortion.
作者信息
Kaptan Kürşat, Beyan Cengiz, Ifran Ahmet, Pekel Aysel
机构信息
Department of Hematology, Gülhane Military Medical Academy, Ankara, Turkey.
出版信息
Int J Gynaecol Obstet. 2008 Sep;102(3):271-4. doi: 10.1016/j.ijgo.2008.04.007. Epub 2008 Jun 11.
OBJECTIVE
To investigate the significance of platelet-derived microparticles (PMPs) in women with recurrent spontaneous abortion.
METHODS
We measured platelet P-selectin (CD62P) as a platelet activation marker and CD42b(+) microparticles as PMPs by flow cytometry in whole blood of 20 women with recurrent spontaneous abortion and 20 age-matched healthy controls with no previous history of spontaneous abortion.
RESULTS
PMP levels in women with recurrent spontaneous abortion were higher than in women in the control group (4.79+/-1.18% vs 3.06+/-0.92%; P<0.000). CD62P levels were not significantly higher in the study group compared with the control group (13.78+/-8.62% vs 10.78+/-7.35%; P>0.05).
CONCLUSION
Our findings suggest that PMPs may have a role in the pathogenesis of recurrent spontaneous abortion.
目的
探讨血小板衍生微粒（PMPs）在复发性自然流产女性中的意义。
方法
我们通过流式细胞术测量了20例复发性自然流产女性和20例年龄匹配、无自然流产史的健康对照者全血中作为血小板活化标志物的血小板P选择素（CD62P）以及作为PMPs的CD42b(+)微粒。
结果
复发性自然流产女性的PMP水平高于对照组女性（4.79±1.18%对3.06±0.92%；P<0.000）。与对照组相比，研究组的CD62P水平无显著升高（13.78±8.62%对10.78±7.35%；P>0.05）。
结论
我们的研究结果表明，PMPs可能在复发性自然流产的发病机制中起作用。
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