Tongiorgi Enrico
BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Via Giorgieri 10, 34127 Trieste, Italy.
Neurosci Res. 2008 Aug;61(4):335-46. doi: 10.1016/j.neures.2008.04.013. Epub 2008 May 4.
Long-lasting synaptic changes in transmission and morphology at the basis of memory storage, require delivery of newly synthesized proteins to affected synapses. Although many of these proteins are generated in the cell body, several key molecules for plasticity can be delivered in the form of silent mRNAs at synapses in extra somatic compartments where they are locally translated. One of such mRNAs encodes brain-derived neurotrophic factor (BDNF), a key molecule in neuronal development, learning and memory. A single BDNF protein is produced from several splice variants having a different 5' untranslated region. These mRNA variants have a different subcellular localization (soma, proximal or distal dendritic compartment) and may represent a spatial code for a local control of BDNF availability. This review will highlight current knowledge on the mechanisms of spatial and temporal regulation of activity-dependent BDNF mRNA localization in dendrites in relation with synaptic plasticity.
记忆存储所依赖的持久的突触传递和形态变化，需要将新合成的蛋白质输送到受影响的突触。虽然这些蛋白质中的许多是在细胞体中产生的，但一些可塑性关键分子可以以沉默mRNA的形式输送到体细胞外区室的突触中，并在那里进行局部翻译。其中一种mRNA编码脑源性神经营养因子（BDNF），它是神经元发育、学习和记忆中的关键分子。单个BDNF蛋白由几种具有不同5'非翻译区的剪接变体产生。这些mRNA变体具有不同的亚细胞定位（胞体、近端或远端树突区室），可能代表了一种用于局部控制BDNF可用性的空间编码。本综述将重点介绍当前关于与突触可塑性相关的树突中活性依赖性BDNF mRNA定位的时空调节机制的知识。
