INMED (Institut de Neurobiologie de la Méditerranée), INSERM (Institut National de la Santé et de la Recherche Médicale Unité 901), Marseille, France.
Eur J Neurosci. 2010 Oct;32(8):1239-44. doi: 10.1111/j.1460-9568.2010.07378.x. Epub 2010 Sep 30.
During the last decade, a major role has emerged for brain-derived neurotrophic factor (BDNF) in the translation of intrinsic or sensory-driven synaptic activities into the neuronal network plasticity that sculpts neural circuits. BDNF is released from dendrites and axons in response to synaptic activity and modulates many aspects of synaptic function. Although the importance of BDNF in synaptic plasticity has been clearly established, direct evidence for a specific contribution of the activity-dependent dendritic secretion of BDNF has been difficult to obtain. This review summarizes recent advances that have established specific effects of postsynaptic BDNF secretion on synapse efficacy and development. We will also discuss these data in the light of their functional and pathological significance.
在过去的十年中，脑源性神经营养因子（BDNF）在将内在或感觉驱动的突触活动转化为塑造神经网络的神经元网络可塑性方面发挥了重要作用。BDNF 是从树突和轴突中释放出来的，以响应突触活动，并调节突触功能的许多方面。尽管 BDNF 在突触可塑性中的重要性已经得到明确证实，但关于 BDNF 活性依赖性树突分泌的具体贡献的直接证据很难获得。这篇综述总结了最近的进展，这些进展确立了突触后 BDNF 分泌对突触效能和发育的特定影响。我们还将根据其功能和病理意义讨论这些数据。
