Foldvari Marianna, Bagonluri Mukasa
School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada.
Nanomedicine. 2008 Sep;4(3):173-82. doi: 10.1016/j.nano.2008.04.002. Epub 2008 Jun 11.
Carbon nanotubes (CNTs) are considered potential biomedical materials because of their flexible structure and propensity for chemical functionalization. In the first part of this two-part review we focus on the properties and use of CNTs as building blocks for novel drug delivery systems, dosage forms, and biomedical substrates. Pharmaceutical excipients have been regarded as inert or nonactive components of dosage forms, but they are essential and necessary components of pharmaceutical preparations. Here we present a collection of data to initiate the description of CNTs as pharmaceutical excipients. We summarize the synthesis, purification, and analysis of CNTs related to their pharmaceutical properties and quality control. Application of CNTs in biological systems depends on their compatibility with hydrophilic environments; therefore, the solubilization of CNTs in pharmaceutical solvents is essential. Furthermore, because it is becoming increasingly important that the relevant chemical, physiochemical, and pharmaceutical properties of CNTs be identified, we have prepared a "mini-monograph" of CNTs that compiles their pertinent properties.
碳纳米管（CNTs）因其灵活的结构和易于化学功能化的特性而被视为潜在的生物医学材料。在这篇分为两部分的综述的第一部分中，我们重点关注碳纳米管作为新型药物递送系统、剂型和生物医学基质的构建单元的性质和用途。药用辅料一直被视为剂型中的惰性或非活性成分，但它们是药物制剂中必不可少的成分。在此，我们提供一系列数据，以开启将碳纳米管描述为药用辅料的论述。我们总结了与碳纳米管的药物性质和质量控制相关的合成、纯化及分析方法。碳纳米管在生物系统中的应用取决于它们与亲水环境的相容性；因此，碳纳米管在药用溶剂中的增溶至关重要。此外，鉴于识别碳纳米管相关的化学、物理化学和药物性质变得越来越重要，我们编写了一份碳纳米管的“小型专题论文”，汇编了它们的相关性质。
