Rossetti F, Messina C, Colleselli P, De Silvestro G, Sotti G, Destro R, Zanesco L
Department of Pediatrics, Padova Hospital, Italy.
Bone Marrow Transplant. 1991;7 Suppl 3:131-2.
Acute non lymphocytic leukemia (AnLL) is the most common second malignancy (SM) in survivors of childhood Hodgkin's Disease (HD). Chemotherapy responsiveness is usually poor and death ensues briefly after diagnosis. We report the case of a 13 year-old girl, affected by HD, stage IV, mixed cellularity, who developed AnLL one year after the HD treatment was stopped. Autologous Bone Marrow Transplantation (ABMT) was performed 9 months after complete remission (CR) was achieved by chemotherapy. Presently, the patient is alive and on continues CR, 3 years and 7 months after ABMT. ABMT may be a promising approach for secondary AnLL, the prognosis of which is almost invariably fatal with conventional chemotherapy.
急性非淋巴细胞白血病（AnLL）是儿童霍奇金病（HD）幸存者中最常见的第二种恶性肿瘤（SM）。化疗反应通常较差，诊断后不久即死亡。我们报告了一例13岁女孩的病例，该女孩患有IV期混合细胞型HD，在HD治疗停止一年后发生了AnLL。在化疗达到完全缓解（CR）9个月后进行了自体骨髓移植（ABMT）。目前，患者在ABMT后3年7个月仍存活且持续处于CR状态。ABMT可能是继发性AnLL的一种有前景的治疗方法，而传统化疗对继发性AnLL的预后几乎总是致命的。
