Speakman John R, Rance Kellie A, Johnstone Alexandra M
Division of Obesity and Metabolic Health, Rowett Research Institute, Aberdeen, Scotland, UK.
Obesity (Silver Spring). 2008 Aug;16(8):1961-5. doi: 10.1038/oby.2008.318. Epub 2008 Jun 12.
The FTO gene has significant polymorphic variation associated with obesity, but its function is unknown. We screened a population of 150 whites (103F/47M) resident in NE Scotland, United Kingdom, for variants of the FTO gene and linked these to phenotypic variation in their energy expenditure (basal metabolic rate (BMR) and maximal oxygen consumption VO(2)max) and energy intake. There was no significant association between the FTO genotype and BMR or VO(2)max. The FTO genotype was significantly associated (P = 0.024) with variation in energy intake, with average daily intake being 9.0 MJ for the wild-type TT genotype and 10.2 and 9.5 MJ for the "at risk" AT and AA genotypes, respectively. Adjusting intake for BMR did not remove the significance (P = 0.043). FTO genotype probably affects obesity via effects on food intake rather than energy expenditure.
FTO基因存在与肥胖相关的显著多态性变异,但其功能尚不清楚。我们对居住在英国苏格兰东北部的150名白人(103名女性/47名男性)群体进行了FTO基因变异筛查,并将这些变异与他们的能量消耗(基础代谢率(BMR)和最大耗氧量VO₂max)及能量摄入的表型变异联系起来。FTO基因型与BMR或VO₂max之间无显著关联。FTO基因型与能量摄入变异显著相关(P = 0.024),野生型TT基因型的平均每日摄入量为9.0兆焦耳,“风险”型AT和AA基因型的平均每日摄入量分别为10.2兆焦耳和9.5兆焦耳。对BMR进行摄入量调整后,这种显著性仍然存在(P = 0.043)。FTO基因型可能通过影响食物摄入量而非能量消耗来影响肥胖。