FTO基因多态性对韩国人群体重指数遗传效应的复制研究。
Replication of genetic effects of FTO polymorphisms on BMI in a Korean population.
作者信息
Cha Seong W, Choi Sun M, Kim Kil S, Park Byung L, Kim Jae R, Kim Jong Y, Shin Hyoung D
机构信息
Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon, Korea.
出版信息
Obesity (Silver Spring). 2008 Sep;16(9):2187-9. doi: 10.1038/oby.2008.314.
It has been newly reported in recent studies that single-nucleotide polymorphisms (SNPs) in the first intron of the FTO gene have been associated with BMI in whites. To determine whether the gene is associated with BMI in Asians also, we performed a replication study of the association of the gene with BMI in a Korean population. Two SNPs in the FTO gene (rs1421085 and rs17817449) were genotyped using the TaqMan method in a Korean population (n = 1,733). The two SNPs were then used for an association study with BMI through statistical analyses. The rs1421085 C allele (P = 0.0015, effect size = 0.0056) and rs17817449 G allele (P = 0.0019, effect size = 0.0053) were found to be significantly associated with increased BMI. Our results suggest that FTO may be one of the worldwide obesity-risk genes.
最近的研究新报道称，FTO基因第一内含子中的单核苷酸多态性（SNP）与白人的体重指数（BMI）相关。为了确定该基因在亚洲人中是否也与BMI相关，我们在韩国人群中进行了该基因与BMI关联的重复研究。采用TaqMan方法对韩国人群（n = 1733）中的两个FTO基因SNP（rs1421085和rs17817449）进行基因分型。然后通过统计分析将这两个SNP用于与BMI的关联研究。发现rs1421085的C等位基因（P = 0.0015，效应大小 = 0.0056）和rs17817449的G等位基因（P = 0.0019，效应大小 = 0.0053）与BMI升高显著相关。我们的结果表明，FTO可能是全球肥胖风险基因之一。
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