Ning Meiwei, Chen Lin, Wang Yuxue, Xu Aohong, Zeng Rong, Zhang Huan, Wang Boda, Liu Xiang
Department of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Heilongjiang University of Chinese Medicine Jiamusi College, Jiamusi, China.
Int J Endocrinol. 2024 Oct 24;2024:8062791. doi: 10.1155/2024/8062791. eCollection 2024.
Fat mass and obesity-associated gene (FTO) genes rs9939609 is strongly associated with obesity and rs17817449 is an important and potential gene for obesity, have been well established. We aim to evaluate the relationship between FTO gene and overweight/obesity and confirm the influence of obesity on glucose and lipid metabolism parameters. We investigated 183 normal weight subjects and 193 individuals with overweight/obesity. Firstly, the effect of overweight/obesity on glucose and lipid metabolism parameters was analyzed. Then, the FTO genes rs9939609 and rs17817449 were counted to explore whether polymorphisms were associated with overweight/obesity and metabolic parameters. Significant differences existed in glucose and lipid parameters between the group with overweight/obesity and control group. The rs9939609 and rs17817449 were strongly correlated with overweight/obesity. Haplotype analysis revealed that GA and GT haplotypes had 2.99 and 1.81 fold risk of overweight/obesity. FTO polymorphism also has effects on glucose and lipid metabolism parameters. There is a linkage imbalance between rs9939609 and rs17817449 in a Central China general population cohort, which also reflected the influence of FTO gene on the risk of overweight/obesity and total cholesterol (TC), triglyceride (TG), and high-density lipoprotein (HDL) disorders. The new findings could provide new clues to predict obesity and metabolic diseases.
脂肪量与肥胖相关基因（FTO）的rs9939609基因与肥胖密切相关，rs17817449是肥胖的一个重要潜在基因，这一点已经得到充分证实。我们旨在评估FTO基因与超重/肥胖之间的关系，并确认肥胖对糖脂代谢参数的影响。我们调查了183名体重正常的受试者和193名超重/肥胖个体。首先，分析超重/肥胖对糖脂代谢参数的影响。然后，对FTO基因的rs9939609和rs17817449进行计数，以探讨基因多态性是否与超重/肥胖及代谢参数相关。超重/肥胖组与对照组之间的糖脂参数存在显著差异。rs9939609和rs17817449与超重/肥胖密切相关。单倍型分析显示，GA和GT单倍型发生超重/肥胖的风险分别为2.99倍和1.81倍。FTO基因多态性也对糖脂代谢参数有影响。在中国中部普通人群队列中，rs9939609和rs17817449之间存在连锁不平衡，这也反映了FTO基因对超重/肥胖风险以及总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白（HDL）紊乱的影响。这些新发现可为预测肥胖和代谢性疾病提供新线索。
