Topographic analysis of field potentials in rat vibrissa/barrel cortex.

An 8 x 8 multichannel microelectrode array was used to simultaneously record epicortical field potentials, evoked by displacement of contralateral vibrissae, from a 4 x 4 mm2 area of vibrissa/barrel cortex in 4 rats. The epicortical responses began with early positive (P1) and negative (N1) sharp waves, followed by slower positive (P2) and negative (N2) waves. The potential complex systematically shifted location with vibrissa stimulated, in accordance with the known somatotopic anatomy of vibrissa/barrel cortex. Topographical distributions of potentials at the P1, N1, P2 and N2 peaks were approximately concentric, but had distinct spatial extents, suggesting that they were generated by different but overlapping neuronal subpopulations. We propose that the SEP in the vibrissa/barrel cortex is produced by both sequential and parallel processing of somatosensory information, and that all components of the epicortical SEP are generated only in primary somatosensory cortex of the rat. Applications and weaknesses of topographic analysis methods are discussed.