Papoutsakis E T
Department of Chemical Engineering, Rice University, P.O. Box 1892, Houston, Texas 77251, USA.
Biotechnol Bioeng. 1984 Feb;26(2):174-87. doi: 10.1002/bit.260260210.
A stoichiometric equation has been derived which describes the interrelations among the various products and biomass in fermentations of butyric acid bacteria. The derivation of the equation is based on an assumed ATP yield, two biological regularities, and the biochemistry of product formation of the fermentations. The equation obeys the constraints imposed on growth and product formation by thermodynamics and the biochemical topology. The validity of the equation is tested using a variety of fermentation data from the literature. The uses, improvements, limitations, and extensions of the equation are also discussed in detail. For example, the fermentation equation is used to calculate the maximal possible yields of the main fermentation products.
已经推导了一个化学计量方程,该方程描述了丁酸菌发酵中各种产物与生物质之间的相互关系。该方程的推导基于假定的ATP产量、两个生物学规律以及发酵产物形成的生物化学过程。该方程符合热力学和生化拓扑学对生长和产物形成所施加的限制。使用文献中的各种发酵数据对方程的有效性进行了检验。还详细讨论了该方程的用途、改进、局限性及扩展。例如,该发酵方程用于计算主要发酵产物的最大可能产量。