Lindegaard Marie L S, Svarrer Eva M M, Damm Peter, Mathiesen Elisabeth R, Nielsen Lars B
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark.
Diabetes Metab Res Rev. 2008 Sep;24(6):465-71. doi: 10.1002/dmrr.867.
Proatherogenic stimuli during foetal life may predispose to development of atherosclerosis in adulthood. Elevated plasma low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) expression is associated with increased risk of atherosclerosis.
In this study, we examined how maternal type 1 diabetes affects foetal plasma LDL cholesterol and CRP. In comparison with healthy mothers, the plasma LDL cholesterol was not increased in the mothers with diabetes, however, the umbilical-cord plasma LDL cholesterol was increased in their infants. CRP was increased in infants of mothers with diabetes and high haemoglobin A1c (HbA1c, > or = 6.2%). Human placenta expresses microsomal triglyceride transfer protein (MTP), which facilitates secretion of apolipoprotein B-containing lipoproteins. Microsomal triglyceride transfer activity was slightly higher (11%) in placentas from mothers with diabetes and HbA1c > or = 6.2% compared with the controls.
The results suggest that maternal type 1 diabetes increases the foetal plasma LDL cholesterol and CRP concentration and thus might predispose the offspring to development of atherosclerosis.
胎儿期的促动脉粥样硬化刺激因素可能使个体成年后易患动脉粥样硬化。血浆低密度脂蛋白（LDL）胆固醇升高和C反应蛋白（CRP）表达增加与动脉粥样硬化风险增加相关。
在本研究中，我们研究了母亲患1型糖尿病如何影响胎儿血浆LDL胆固醇和CRP。与健康母亲相比，糖尿病母亲的血浆LDL胆固醇并未升高，然而，她们婴儿的脐带血血浆LDL胆固醇升高。糖尿病母亲且血红蛋白A1c（HbA1c，≥6.2%）的婴儿CRP升高。人胎盘表达微粒体甘油三酯转移蛋白（MTP），其促进含载脂蛋白B的脂蛋白的分泌。与对照组相比，糖尿病母亲且HbA1c≥6.2%的胎盘微粒体甘油三酯转移活性略高（11%）。
结果表明，母亲患1型糖尿病会增加胎儿血浆LDL胆固醇和CRP浓度，从而可能使后代易患动脉粥样硬化。
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