1 型和 2 型糖尿病患者妊娠期间血清脂质水平的变化。
Changes in serum lipid levels during pregnancy in type 1 and type 2 diabetic subjects.
机构信息
Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria.
出版信息
Diabetes Care. 2010 Sep;33(9):2071-3. doi: 10.2337/dc10-0484. Epub 2010 Jun 2.
Abstract
OBJECTIVE
Alterations in maternal lipid metabolism could affect fetal programming and the susceptibility for atherosclerosis in the offspring; therefore, we studied differences in lipid profiles of pregnant women with type 1 and type 2 diabetes.
RESEARCH DESIGN AND METHODS
A total of 173 diabetic pregnancies were studied prior to conception (V0), at each trimester (V1-V3), and after delivery and were compared with 137 healthy women at V3.
RESULTS
During gestation, the increase in serum lipid concentrations was less pronounced in type 2 diabetic subjects. At V3, the lipid levels of type 1 diabetic women with normal glucose tolerance were similar but significantly higher then those of type 2 diabetic women. Elevated triglycerides and low HDL cholesterol at V3 were significant predictors for large-for-gestational-age (LGA) newborns.
CONCLUSIONS
Our data suggest smaller changes in serum lipid concentrations during pregnancy in type 2 diabetic mothers. Additionally, we found a positive association between maternal triglycerides and LGA infants independently of chronic glycemic control.
摘要
目的
母体脂代谢的改变可能会影响胎儿的编程以及后代发生动脉粥样硬化的易感性；因此，我们研究了 1 型和 2 型糖尿病孕妇的血脂谱差异。
研究设计和方法
共研究了 173 例糖尿病妊娠患者，分别在受孕前（V0）、每个孕期（V1-V3）和分娩后进行研究，并与 V3 时的 137 例健康女性进行了比较。
结果
在妊娠期间，2 型糖尿病患者的血清脂质浓度增加不明显。在 V3 时，血糖正常的 1 型糖尿病女性的血脂水平与 2 型糖尿病女性相似，但明显更高。V3 时升高的甘油三酯和低 HDL 胆固醇是巨大儿（LGA）新生儿的显著预测指标。
结论
我们的数据表明，2 型糖尿病母亲在怀孕期间血清脂质浓度的变化较小。此外，我们发现母体甘油三酯与 LGA 婴儿之间存在正相关，独立于慢性血糖控制。
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