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[上呼吸道局限性淀粉样变性]

[Localized amyloidosis of upper respiratory tract].

作者信息

Pietruszewska Wioletta, Kurnatowska Ilona, Murlewska Anna, Zapała Marta, Wagrowska-Danilewicz Małgorzata

机构信息

Katedra i Klinika Otolaryngologii Uniwersytetu Medycznego w Lodzi.

出版信息

Otolaryngol Pol. 2007;61(5):730-5. doi: 10.1016/S0030-6657(07)70514-0.

Abstract

Amyloidosis results from the deposition of amyloid proteins in organ and tissues. It can be localized or systemic. Amyloidosis may be classified as either primary or secondary. Primary is idiopathic, whereas the secondary form is associated with chronic inflammatory or infectious process. Amyloidosis is also related to myeloma multiplex (plasmacytoma) or located as tumor like deposits in isolated organ without systemic involvement. Localized amyloidosis in the head and neck is rare and can have various manifestations. A case of surgically treated localized amyloidosis of the pharynx is presented. The study is focused on case history, results of laryngeal, general and pathological examination of the patient. Current options on the structure of amyloid, making diagnosis, treatment and prognosis in patients with amyloidosis are presented.

摘要

淀粉样变性是由淀粉样蛋白在器官和组织中的沉积所致。它可分为局限性或全身性。淀粉样变性可分为原发性或继发性。原发性为特发性,而继发性形式与慢性炎症或感染过程相关。淀粉样变性还与多发性骨髓瘤(浆细胞瘤)有关,或表现为孤立器官中的肿瘤样沉积物而无全身受累。头颈部局限性淀粉样变性罕见,可有多种表现。本文介绍一例经手术治疗的咽部局限性淀粉样变性病例。该研究聚焦于患者的病史、喉部、全身及病理检查结果。文中还介绍了淀粉样蛋白结构、淀粉样变性患者的诊断、治疗及预后的当前观点。

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