腮腺局限性淀粉样变性：一例报告及头颈部局限性淀粉样变性的文献复习

Localized amyloidosis of the parotid gland: a case report and review of the localized amyloidosis of the head and neck.

作者信息

Nandapalan V, Jones T M, Morar P, Clark A H, Jones A S

机构信息

Department of Otolaryngology, University of Liverpool, UK.

出版信息

Head Neck. 1998 Jan;20(1):73-8. doi: 10.1002/(sici)1097-0347(199801)20:1<73::aid-hed12>3.0.co;2-q.

DOI:10.1002/(sici)1097-0347(199801)20:1<73::aid-hed12>3.0.co;2-q

PMID:9464956

Abstract

BACKGROUND

Localized amyloidosis in the head and neck is a rare and benign process.

METHODS

We present the first case report in the literature of localized amyloidosis of the parotid glands and also comprehensively review the literature regarding localized amyloidosis of the head and neck.

RESULTS

Amyloidosis affecting the head and neck region is uncommon and is mostly in the form of localized amyloidosis. Larynx is the commonest site of involvement and accounts for 0.2% to 0.5% of benign laryngeal tumors. Laryngeal involvement could be either diffuse subepithelial deposition or discrete tumor nodules. Although localized amyloidosis occurs much more frequently in the oral cavity and pharynx, only seven cases of nasopharyngeal amyloidosis and eight cases of nasal septum amyloidosis have been reported. There is no documentation to suggest that localized amyloidosis can progress to systemic amyloidosis. Local surgical excision is the treatment of choice for laryngeal amyloidosis and laser excision is probably the best.

CONCLUSION

While localized amyloidosis of the head and neck region is rare, it should be recognized, understood, evaluated, and properly treated.

摘要

背景

头颈部局限性淀粉样变性是一种罕见的良性病变。

方法

我们报告了腮腺局限性淀粉样变性的首例文献病例，并全面回顾了关于头颈部局限性淀粉样变性的文献。

结果

累及头颈部区域的淀粉样变性并不常见，主要表现为局限性淀粉样变性。喉部是最常受累的部位，占良性喉部肿瘤的0.2%至0.5%。喉部受累可为弥漫性上皮下沉积或离散的肿瘤结节。尽管局限性淀粉样变性在口腔和咽部更为常见，但仅报道了7例鼻咽部淀粉样变性和8例鼻中隔淀粉样变性。没有文献表明局限性淀粉样变性可进展为系统性淀粉样变性。局部手术切除是喉部淀粉样变性的首选治疗方法，激光切除可能是最佳选择。