内分泌干细胞调节的生理基础。
The physiological basis of intracrine stem cell regulation.
作者信息
Re Richard N, Cook Julia L
机构信息
Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
出版信息
Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H447-53. doi: 10.1152/ajpheart.00461.2008. Epub 2008 Jun 13.
Abstract
Intracrine peptides and proteins participate in the regulation of adult and pleuripotential embryonic-like stem cells. Included among these factors are VEGF, dynorphin, the readthrough form of acetylcholinesterase, Oct3/4, Pdx-1, Pax-6, and high-mobility group protein B1, among others. In some cases, the establishment of intracrine feedback loops can be shown to be relevant to this regulation, consistent with previously proposed principles of intracrine action. Here the role of intracrines in stem cell regulation is reviewed, with particular attention to the intracrine regulation of cardiac stem cells. The reprogramming of cells to restore the pleuripotent phenotype and the possible role of stem/progenitor cells in neoplasia are also discussed.
摘要
内分泌肽和蛋白质参与成体及多能胚胎样干细胞的调节。这些因子包括血管内皮生长因子（VEGF）、强啡肽、乙酰胆碱酯酶的通读形式、八聚体结合转录因子3/4（Oct3/4）、胰腺十二指肠同源盒-1（Pdx-1）、配对盒基因6（Pax-6）以及高迁移率族蛋白B1等。在某些情况下，内分泌反馈回路的建立与这种调节相关，这与先前提出的内分泌作用原理一致。本文综述了内分泌物质在干细胞调节中的作用，特别关注心脏干细胞的内分泌调节。还讨论了细胞重编程以恢复多能表型以及干/祖细胞在肿瘤形成中的可能作用。
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