Ochsner Clinic Foundation, 1514 Jefferson Hwy., New Orleans, LA 70121, USA.
Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H577-83. doi: 10.1152/ajpheart.00421.2010. Epub 2010 Jul 9.
In recent years the actions of intracellular-acting, extracellular signaling proteins/peptides (intracrines) have become increasingly defined. General principles of intracrine action have been proposed. Mitochondria represent one locus of intracrine action, and thus far, angiotensin II, transforming growth factor-beta, growth hormone, atrial natriuretic peptide, Wnt 13, stanniocalcin, other renin-angiotensin system components, and vascular endothelial-derived growth factor, among others, have been shown to be mitochondria-localizing intracrines. The implications of this mitochondrial intracrine biology are discussed.
近年来，细胞内作用的细胞外信号蛋白/肽（胞内蛋白）的作用越来越明确。胞内蛋白作用的一般原则已经提出。线粒体代表胞内蛋白作用的一个位置，到目前为止，血管紧张素 II、转化生长因子-β、生长激素、心钠素、Wnt13、斯钙素、其他肾素-血管紧张素系统成分和血管内皮衍生生长因子等已被证明是定位于线粒体的胞内蛋白。讨论了这种线粒体胞内生物学的意义。
