Krediet Raymond T, Coester Annemieke M, Parikova Alena, Smit Watske, Struijk Dirk G
Academic Medical Center, Division of Nephrology, Department of Medicine, PO Box 22700, Amsterdam 1100 DE Netherlands.
Perit Dial Int. 2008 Jun;28 Suppl 3:S144-9.
A review is given on the mechanisms of free water transport, the various methodologies for its measurement, its dependency on the osmotic gradient, and the assessment of osmotic conductance in individual patients. The importance of impaired free water transport in long-term ultrafiltration failure is discussed, relative to peritoneal solute transport status. Furthermore, the relationship of free water transport with locally released potassium is considered, together with a potential role of impaired K(+) channel function with peritoneal alterations. Finally, the role of impaired osmotic conductance to glucose and its effects on free water transport in long-term patients with ultrafiltration failure is reviewed.
本文综述了自由水转运的机制、其测量的各种方法、其对渗透梯度的依赖性以及个体患者渗透传导性的评估。讨论了自由水转运受损在长期超滤失败中的重要性，相对于腹膜溶质转运状态而言。此外，还考虑了自由水转运与局部释放钾的关系，以及钾通道功能受损与腹膜改变的潜在作用。最后，综述了渗透传导性受损对葡萄糖的作用及其对长期超滤失败患者自由水转运的影响。
