Suppr超能文献

在离体猪心脏的心室颤动过程中,心外膜波前源自广泛分布的瞬态源。

Epicardial wavefronts arise from widely distributed transient sources during ventricular fibrillation in the isolated swine heart.

作者信息

Rogers J M, Walcott G P, Gladden J D, Melnick S B, Ideker R E, Kay M W

机构信息

Department of Biomedical Engineering, University of Alabama at Birmingham, 1670 University Blvd., Volker Hall B140, Birmingham, AL 35294, USA.

出版信息

New J Phys. 2008 Jan 31;10(1):015004. doi: 10.1088/1367-2630/10/1/015004.

Abstract

It has been proposed that VF waves emanate from stable localized sources, often called "mother rotors." However, evidence for the existence of these rotors is conflicting. Using a new panoramic optical mapping system that can image nearly the entire ventricular epicardium, we recently excluded epicardial mother rotors as the drivers of Wiggers' stage II VF in the isolated swine heart. Furthermore, we were unable to find evidence that VF requires sustained intramural sources. The present study was designed to test the following hypotheses: 1. VF is driven by a specific region, and 2. Rotors that are long-lived, though not necessarily permanent, are the primary generators of VF wavefronts. Using panoramic optical mapping, we mapped VF wavefronts from 6 isolated swine hearts. Wavefronts were tracked to characterize their activation pathways and to locate their originating sources. We found that the wavefronts that participate in epicardial reentry were not confined to a compact region; rather they activated the entire epicardial surface. New wavefronts feeding into the epicardial activation pattern were generated over the majority of the epicardium and almost all of them were associated with rotors or repetitive breakthrough patterns that lasted for less than 2 s. These findings indicate that epicardial wavefronts in this model are generated by many transitory epicardial sources distributed over the entire surface of the heart.

摘要

有人提出室颤波源自稳定的局部源,通常称为“母转子”。然而,这些转子存在的证据相互矛盾。我们使用一种新的全景光学标测系统,该系统能够对几乎整个心室心外膜进行成像,最近我们排除了心外膜母转子是离体猪心脏中维格斯氏二期室颤驱动因素的可能性。此外,我们未能找到证据表明室颤需要持续的壁内源。本研究旨在检验以下假设:1. 室颤由特定区域驱动;2. 寿命长但不一定永久的转子是室颤波前的主要发生器。我们使用全景光学标测技术,对6个离体猪心脏的室颤波前进行了标测。追踪波前以表征其激活途径并确定其起源。我们发现,参与心外膜折返的波前并不局限于一个紧凑区域;相反,它们激活了整个心外膜表面。进入心外膜激活模式的新波前在大部分心外膜上产生,并且几乎所有这些波前都与持续时间小于2秒的转子或重复突破模式相关。这些发现表明,该模型中的心外膜波前是由分布在心脏整个表面的许多短暂心外膜源产生的。

相似文献

2
Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart.
Biophys J. 2007 Feb 1;92(3):1090-5. doi: 10.1529/biophysj.106.092098. Epub 2006 Nov 10.
3
Epicardial rotors in panoramic optical maps of fibrillating swine ventricles.
Conf Proc IEEE Eng Med Biol Soc. 2006;2006:2268-71. doi: 10.1109/IEMBS.2006.260635.
4
Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles.
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1935-41. doi: 10.1152/ajpheart.00276.2006. Epub 2006 Apr 21.
5
Sustained reentry in the left ventricle of fibrillating pig hearts.
Circ Res. 2003 Mar 21;92(5):539-45. doi: 10.1161/01.RES.0000061569.23879.20. Epub 2003 Feb 13.
6
Epicardial organization of human ventricular fibrillation.
Heart Rhythm. 2004 May;1(1):14-23. doi: 10.1016/j.hrthm.2004.01.007.
7
Ventricular fibrillation in myopathic human hearts: mechanistic insights from in vivo global endocardial and epicardial mapping.
Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2589-97. doi: 10.1152/ajpheart.01336.2006. Epub 2007 Jan 26.
8
Intramural activation during early human ventricular fibrillation.
Circ Arrhythm Electrophysiol. 2011 Oct;4(5):692-703. doi: 10.1161/CIRCEP.110.961037. Epub 2011 Jul 12.
9
Evolution of the organization of epicardial activation patterns during ventricular fibrillation.
J Cardiovasc Electrophysiol. 1998 Dec;9(12):1291-1304. doi: 10.1111/j.1540-8167.1998.tb00105.x.
10
Our search for the porcine mother rotor.
Ann Noninvasive Electrocardiol. 2005 Oct;10(4 Suppl):7-15. doi: 10.1111/j.1542-474X.2005.00071.x.

引用本文的文献

1
RHYTHM: An Open Source Imaging Toolkit for Cardiac Panoramic Optical Mapping.
Sci Rep. 2018 Feb 13;8(1):2921. doi: 10.1038/s41598-018-21333-w.
2
Dynamics of spatiotemporal line defects and chaos control in complex excitable systems.
Sci Rep. 2017 Aug 10;7(1):7757. doi: 10.1038/s41598-017-08011-z.
3
Verapamil reduces incidence of reentry during ventricular fibrillation in pigs.
Am J Physiol Heart Circ Physiol. 2014 Nov 1;307(9):H1361-9. doi: 10.1152/ajpheart.00256.2014. Epub 2014 Aug 29.

本文引用的文献

1
Organization of ventricular fibrillation in the human heart.
Circ Res. 2007 Jun 22;100(12):e87-101. doi: 10.1161/CIRCRESAHA.107.150730. Epub 2007 May 31.
2
Panoramic optical mapping reveals continuous epicardial reentry during ventricular fibrillation in the isolated swine heart.
Biophys J. 2007 Feb 1;92(3):1090-5. doi: 10.1529/biophysj.106.092098. Epub 2006 Nov 10.
3
Low osmolarity transforms ventricular fibrillation from complex to highly organized, with a dominant high-frequency source.
Heart Rhythm. 2006 Oct;3(10):1210-20. doi: 10.1016/j.hrthm.2006.06.026. Epub 2006 Jul 8.
4
Evidence for multiple mechanisms in human ventricular fibrillation.
Circulation. 2006 Aug 8;114(6):536-42. doi: 10.1161/CIRCULATIONAHA.105.602870. Epub 2006 Jul 31.
5
Lifetimes of epicardial rotors in panoramic optical maps of fibrillating swine ventricles.
Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1935-41. doi: 10.1152/ajpheart.00276.2006. Epub 2006 Apr 21.
6
Mechanisms of ventricular fibrillation in canine models of congestive heart failure and ischemia assessed by in vivo noncontact mapping.
Circulation. 2005 Sep 13;112(11):1532-41. doi: 10.1161/CIRCULATIONAHA.104.521351. Epub 2005 Sep 6.
7
9
Epicardial organization of human ventricular fibrillation.
Heart Rhythm. 2004 May;1(1):14-23. doi: 10.1016/j.hrthm.2004.01.007.
10
Three-dimensional surface reconstruction and panoramic optical mapping of large hearts.
IEEE Trans Biomed Eng. 2004 Jul;51(7):1219-29. doi: 10.1109/TBME.2004.827261.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验